… It’s important to choose the right type of B12 for your individual genetics before taking methylfolate to treat the MTHFR gene mutation for depression and anxiety  

MTHFR Treatment for Depression Anxiety and Bipolar

The basic procedure for introducing methylfolate when you have the MTHFR:-
Before supplementing methylfolate you should do the following:-
  1. Prepare the body to handle increased discharge of toxins, this includes basic procedures such as several days of copious hydration, exercises to move the lymphatic system and some exercises are better than others for this purpose, a clean diet free from hydrogenated fats, damaged fats, excessive saturated fats, and excessive omega 6 to omega-3 fats, sufficient fibre to absolutely eliminate constipation and more.Beyond basic procedures there are specific procedures that may apply to you as an individual for example you may need to improve liver function, or clear congestion in your lymph nodes and facilitate lymphatic drainage, eliminate visceral fat which ramps up inflammation throughout your system, or you may need to clear small intestinal bacterial overgrowth and leaky gut and change your large intestines microbiota (bowel flora) from a toxic producing colony to toxic eliminating colony. These are the specific things for which you need the assistance of a qualified practitioner or if you really into self-help you get yourself the appropriate qualifications.
  2. Begin with supplementing low-dose lithium orotate to improve the utilisation of B12.
  3. Introduce the right type of B12 according to your COMT V158M and VDR Taq status.
  4. Introduce magnesium, multiple minerals, a balanced B-Complex containing activated forms of B vitamins including small amounts of methylfolate.
  5. Monitor for detoxification healing reactions and when necessary increase the support the struggling detoxification routes. When the situation is stabilised proceed to the final step.
  6. Now you’re ready to begin supplementing moderate amounts of methylfolate and build it up watching out for signs of over methylation.

Micro dose lithium orotate to utilise B12

You should supplement micro dose of lithium from lithium orotate as part of your MTHFR gene recovery treatment because you could be lithium deficient and it appears lithium changes the body’s utilisation of B12, I have taken B12 when not taking low-dose lithium orotate and it produces no noticeable effects, however when I am already on lithium orotate and I add methyl B12 it has significant effects on my health increasing my energy,. There is insufficient scientific evidence connecting lithium to B12 [i] to backup this assertion I base it on my own personal and clinical observations and those of Dr Amy Yasko.
You may be surprised at the suggestion that you should supplement lithium as part of your MTHFR treatment recovery lithium has a bad reputation for producing harmful side-effects but this only relates to the high dosages of lithium carbonate used in psychiatric medicine not micro doses of lithium from lithium-orotate (see Lithium Orotate Many Health Benefits).
Folate methylation is just one part of the jigsaw, it is the central cog wheel but there are additional processes that require additional vitamin and mineral cofactors for complete methylation metabolism.
There are 7 additional nutrients required for methylation metabolism besides methylfolate:-
  • Active forms of B12
  • Active forms of B6
  • Active forms of B-2
  • Magnesium
  • Trimethylglycine also known as betaine
  • Vitamin D3
Why methylation matters so much
A lack of methylation from the MTHFR gene mutation doesn’t just have one single effect but can cause a wide variety of health problems in different areas.
I discuss methylation in more detail elsewhere but briefly it’s a natural chemical process occurring in every cell of your body whereby a small molecule called a methyl group consisting of just 1 carbon and 3 hydrogen atoms is added or attached to other molecules and in so doing it transform them into something else, for example we need methylation to manufacture serotonin, we use it to break down homocysteine, methylation is such a basic chemical process the body used to transform over 200 substances and if you have inefficient methylation metabolism it can have profound and widespread health consequences including anxiety and depression.
In the brain specifically meets groups are required to manufacture chemicals critical to brain function including:-
  • Serotonin
  • Norepinephrine
  • Epinephrine
  • Melatonin (needed not just for sleep but melatonin is a potent antioxidant used in the brain and digestive system)
  • Glutathione (the main antioxidant the brain and liver used to protect against free radical damage, an inability to protect the brain from oxidative damage due to a lack of glutathione accelerating brain degeneration and ageing, and is believed to play a significant role in some mental health problems)
  • Cysteine (another important antioxidant for the brain)
  • Nitrous oxide (which acts as a neurotransmitter)
  • Taurine (an amino acid especially critical for maintaining and regenerating the health of the hippocampus involved in depression, bipolar, poor memory and other mental health problems)
Lack of methylation can cause health problems throughout the body but I specialise in treating brain and mental health problems with natural remedies and since a lack of methylation can have such a significant impact in this area treating methylation imbalances has become a critical part restoring health to the brains of some of my patients.

Why the MTHFR gene mutation matters so much

Furthermore methylation changes epigenetic proteins that in turn change the expression of every other gene in your body, other genes unrelated to MTHFR. Genes are made of DNA and DNA itself can be methylated and DNA methylation as it is called changes how active a gene will be, whether it is expressed (switched on) or not. Therefore an MTHFR gene mutation influences the activity of all the other genes in the body which is why it is such a key mutation causing so many widespread and diverse health complications and problems; with regard to the brain for example there are genes that control the manufacture of molecules the breakdown serotonin and if those genes are overexpressed you will be breaking down serotonin too quickly and by increasing methylation you can dampen down the overexpression of these genes and therefore increase serotonin activity in your brain producing an antidepressant and antianxiety effect.
I specialise in treating and coaching people with mental health problems how to obtain better mental health with natural remedies and self-help techniques. If you would like me to look into your individual case and develop a tailor-made programme of natural remedies, dietary advice and brain training exercises I’m available for private consultations at my London clinic and online for people that live too far away.
I also run regular meditation classes in London and online.
Click on the 
bookings tab to make an appointment.
I’m passionate about treating mental health and I’d be very happy to work with you.

Personal Anecdote

Through personal experimentation I discovered that methyl B12 (methylcobalamin) had wonderful effects on my health, I had been taking cyanocobalamin (a form of B12 we no longer recommend) for years and when I started taking methyl B12 in a sublingual form I had a significant increase in my physical energy and general sense of well-being but without any manic inducing effects (I have bipolar disorder), furthermore it improved the quality of my sleep and regularity of my sleep-wake cycle. I discovered I got the most energy from 2000 µg a day and that when I increased or decreased the dosage it became less effective so that by 5000 µg I no longer experienced improvements in my energy or sleep. When I switched from methyl B12 to hydroxy and adenosyl B12 as an experiment I completely lost the benefits, remember real-world experimentation is always superior to laboratory testing.
The trick to using B12 for enhanced sleep is to consume a sublingual B12 at the same time as using bright blue light therapy in the morning, this combination enhances natural melatonin production some 16 hours later. See my book Sleep Better with Natural Therapies for more information on how to improve your sleep.
[i] Biol Trace Elem Res. 1992 Aug;34(2):161-76. Lithium in scalp hair of adults, students, and violent criminals. Effects of supplementation and evidence for interactions of lithium with vitamin B12 and with other trace elements. Schrauzer GN, et al PMID: 1381936 DOI: 10.1007/BF02785244
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Hi my name is Peter Smith I specialise in treating and coaching people how to live well with mental health problems, digestive health problems/IBS, sleep problems and type II diabetes using natural therapies.
I used these techniques to overcome and live well with my own bipolar disorder and IBS. I've been in practice as a natural medicine practitioner since 1988.

What I Treat

  • Brain Chemistry and Mental Health problems (depression, anxiety, bipolar disorder, addiction, OCD)
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If you’d like treatment for any of the issues discussed in this article I specialise in treating and coaching people how to obtain better mental health with natural remedies and self-help techniques. If you would like me to look into your individual case and develop a tailor-made programme of natural remedies, dietary advice and brain training exercises I’m available for private consultations and I’m available for private consultations at my London clinic and online for people that live too far away.
I also run regular meditation classes in London and online.
I’m passionate about treating mental health and I’d be very happy to work with you.
Click on the
bookings tab to make an appointment.
To Book an Appointment
At my London clinic please call the Hale clinic reception:
020 7631 0156
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