Stimulating and activating the vagus nerve for treatment resistant depression, IBS and SIBO , Stress inhibits activity in the vagus nerve contributing to depression and digestive health problems

Vagus Nerve Stimulation

for depression, IBS and SIBO

PeterSmithUK.com © 2017 (#1)
 

Herbal Remedies to stimulate the vagus nerve and intestinal cleansing (prokinetics)

When food residue lingers in the small intestines for too long due to a lack of motility in the small intestines specifically diminished migrating motor complex (MMC) movements the food residue encourages an overgrowth of bacteria (SIBO) that can cause bloating, IBS, leaky gut syndrome and this can contribute to inflammation which can have far-reaching harmful effects.
 
There are several drugs and herbs that can stimulate gut motility, remedies that stimulate gut motility are called prokinetics; combine these with the other techniques to re-establish healthy gut motility. If you combine all the techniques below you could experience good improvements in weeks however it can take 9-18 months before you have fully restored healthy gut motility that runs automatically as it should do without needing any assistance from herbal/drug remedies.
 
Something I want to strongly emphasise is that if you just rely on the herbal remedies or drugs without doing all the other things below particularly the relaxation response brain training exercise then you are likely to not achieve as optimal result as you would if you used all the techniques; in my practice I have seen some people that just took the herbal remedies/drugs and didn’t do all the other techniques have to continue taking the herbal/drug prokinetics indefinitely, i.e. even after 18 months or 2 years taking the prokinetics if they try to give them up they still haven’t fully restored natural gut motility and before too long the bacteria in the colon crept its back up into the small intestines causing SIBO/IBS and a leaky gut again, consider yourself warned!
 
Lower Bowel Formula (Dr Christophers)
1 or 2 capsules with each meal 6 days per week only.
 
https://www.iherb.com/pr/Christopher-s-Original-Formulas-Lower-Bowel-Formula-450-mg-100-Veggie-Caps/6354
 
##you can also find this formula on the UK Amazon and www.iherb.com
 
You are just the number of capsules according to the consistency of your bowel motions:
Take more capsules if you are constipated or bloated and fewer if your bowels become loose. 
 
A typical dose might be:
1 capsule at breakfast
1-2 capsules at lunch and
2 capsules with dinner or the largest meal of the day.
 
The minimum dose should be 1 with each meal.  You may take up to 5 capsules with each meal if you’re seriously constipated.  When you take a very high dose you may get temporary cramping in your colon and diarrhoea.
 
In the first few weeks of the cleanse you may need to vary the dosage frequently as your body adjusts to the herbs and you eliminate bacterial biofilm.
 
Iberogast [i]
20 drops 3 times a day 6 days a week
You can easily find iberogast online.
https://iberogast.com.au/
 
Magnolia Bark (also called Hou Po)
1 teaspoon (1.5 g) as a tea twice a day ideally before meals on an empty stomach but take after a meal if this causes an upset stomach.
To take mixed with a little water to make a paste and then add hot but not boiling water and drunk as a tea. You can mix all herbal powders together into one drink.
 
The primary effect we are after from Magnolia bark is its ability to boost BDNF however it also has an antidepressant and antianxiety effect.
 
To find this herb search for Hou Po powder
 
Available from the following suppliers:
https://www.activeherb.com/extract/houpo.shtml
 
In the UK:
http://healthylicious.co.uk/hou-po-magnolia-bark-p-1406.html
 
If this is not available a less than ideal but still effective product is:
http://www.amazon.co.uk/MAGNOLIA-tablets-digestion-relieving-menstrual/dp/B011GKOIUA/ref=sr_1_15?s=drugstore&ie=UTF8&qid=1457400080&sr=1-15&keywords=Magnolia+Bark
3 tablets twice a day with meals.
 
Ginger
You can add a piece of ginger the size of half of your thumb to smoothies, alternatively you can take ginger capsules I recommend: https://www.iherb.com/pr/Jarrow-Formulas-Ginger-500-mg-100-Capsules/204
Ginger is already included in the Dr Christophers Lower Bowel Formula so it’s only an optional extra which you can try to see if it improves your gut health.
 
Take the prokinetic herbs only six days per week.  If you take them seven days per week your body get used to the herbs and you will quite quickly become immune to the benefits.
 

Nutritional supplements to support and intensify the prokinetic herbal formulas

Adding choline and inositol, pantothenic acid (B5) and magnesium intensifies the effectiveness of the prokinetic herbs:
 
Choline and Inositol
1000 mg (1000 mg of choline and 1000 mg of inositol) twice a day with breakfast and dinner.
 
Any good brand is suitable I recommend:
https://www.iherb.com/pr/Now-Foods-Choline-Inositol-500-mg-100-Capsules/513
Choline is converted into the neurotransmitter acetylcholine which stimulates the parasympathetic nervous system, stimulates bile flow from the liver/gallbladder and this stimulates migrating motor complex motility. You could take choline on its own but for some people bipolar disorder choline on its own can be imbalance in but taken with inositol will tend to avoid this potential issue. (See choline and bipolar disorder).
 
Pantothenic Acid
2000 mg twice a day with breakfast and dinner.
 
I recommend Solgar or Now Foods:
https://www.iherb.com/pr/Now-Foods-Pantothenic-Acid-500-mg-250-Capsules/326
Pantothenic acid is also a useful herb for stimulating regeneration of exhausted adrenals however to achieve this it has to be taken in quite high doses say 4 to 6 g twice a day, it’s a very safe, doses as high as 18 g a day may cause a laxative effect.
 
Magnesium Citrate
2 tablets twice a day with breakfast and dinner
 
https://www.iherb.com/pr/Now-Foods-Magnesium-Citrate-200-mg-250-Tablets/691
 

Probiotics to regulate gut motility

It will come as no surprise that specific bacteria influence intestinal activity including gut motility.
Useful bacteria with prokinetic effects include Lactobacillus rhamnous, bifidobacteria lactis, Bifidobacterium bifidum when combined with Lactobacillus acidophilus; lactobacillus plantarum increases the frequency of bowel motions and reduces allergies/sensitivities particularly gluten. Unfortunately not every strain of a specific bacteria produces the same effects and is still difficult to reliably obtain good quality probiotics with specific desirable therapeutic effects.
 
Tranquil Tract
2 capsules once a day in between meals.
https://www.iherb.com/pr/Life-Extension-Tranquil-Tract-60-Veggie-Caps/67009
The specific bacteria contained in tranquil tract have proven effectiveness at regulating gut motility.
 
Primadophillus reuteri
1-2 capsules once a day with or without meals taken separately several hours apart from the Tranquil Tract probiotic.
https://www.iherb.com/pr/Nature-s-Way-Primadophilus-Reuteri-Superior-Probiotic-90-Veggie-Caps/4674
This specific probiotic formula contains lactobacillus reuteri which promotes GABA production in the intestines which travels up the vagus nerve moderating anxiety and overactive stress physiology in the HPA axis and autonomic nervous system; it also contains lactobacillus rhamnous which increases MMC activity and combats invading pathogenic bacteria (food poisoning).
 

Neurotransmitters to stimulate gut motility

There are 2 neurotransmitters that play a role here, increasing acetylcholine stimulates activity in the vagus nerve, the choline in the choline and inositol supplement above is converted into an can increase acetylcholine; the other neurotransmitter involved in initiating intestinal motility is serotonin, in fact it is believed that we produce more serotonin in our digestive system than we do in our brains. We can increase serotonin levels with drugs and some natural remedies, the preferred natural remedy I use in my practice for delivering extra serotonin to the digestive system is 5 HTP, when I want to deliver more serotonin to the brain I prefer to administer tryptophan which crosses the blood-brain barrier more readily before conversion into 5 HTP and then serotonin; the 5 HTP already being close to serotonin converts more readily in the gut and on the outside of the blood-brain barrier where we want it to increase intestinal motility. As with all remedies you should experiment with 5 HTP to see how it actually affects you in the real world.
 
5 HTP
50-100 mg 20 minutes before meals 3 times a day.
I recommend Now Foods or Solgar available from iherb.com
 
CAUTION:
You should not take 5 HTP or tryptophan at the same time as taking an SSRI or SNRI antidepressant.
You should not take 5 HTP or tryptophan without also supplementing B6, zinc and magnesium to make sure that you are not deficient of these essential nutrients, taking 5 HTP or tryptophan without sufficient levels of these essential cofactors may result in the formation of inflammatory and neurotoxic quinolinic acid as opposed to the desired serotonin.
You should not take 5 HTP or tryptophan without also starting to perform deep relaxation brain training exercises, taking these nutrients at the same time are still having overactive stress physiology can also result in formation of neurotoxic quinolinic acid as opposed to the desired serotonin.
 

Essential nutritional cofactors

We need to make sure we are not deficient in any essential cofactors for the other main remedies to work to achieve this supplement omega-3, magnesium, B complex and trace minerals.

For a prescription of which brands to choose for maximum effectiveness, the dosages in which specific type of magnesium huge your digestive health situation I'm available for consultations either at my London clinic or via Skype for people that live too far away. See Fees
 
Super Omega-3 with Sesame Lignin and Olive Oil
This comes in two sizes:
the 120 capsule bottle contains 700 mg of EPA per 2 capsules and
the 240 capsule bottle contains 700 mg of EPA per 4 capsules
If you get the stronger (120 capsule size) capsules take 3 per day and
If you get the smaller (240 capsule size) capsules take 6 per day.
Divided between 2 or ideally 3 meals.
 
Some people find if they take the fish oil supplement after a meal it gives them an upset stomach so always take it at the start of your meal so that the food sits on top of it.
Omega-3 fish oils are very delicate and breakdown when exposed to light and heat so it’s important to keep them in the fridge or ideally the freezer and avoid exposing them to direct sunlight.
 
http://www.iherb.com/Life-Extension-Omega-Foundations-Super-Omega-3-120-Softgels/67018
This product is also available as a triple pack at a good price from the UK Amazon
 
Life Extension Two per Day
1 capsule twice a day with breakfast and dinner.
This multiple vitamin/mineral contains methylfolate in place of folic acid, we must avoid the possibility that you have the genetic intolerance to folic acid which means folic acid it blocks your ability to manufacture neurotransmitters and control inflammation in your brain. It also contains the right type of methylcobalamin or B12 which further reduces inflammation in place of the more typical cyanocobalamin.
https://www.iherb.com/pr/Life-Extension-Two-Per-Day-Tablets-120-Tablets/71780
This is also available in capsules which are easier to swallow.
 

Understanding the vagus autonomic nervous system

The vagus nerve is part of the autonomic nervous system, the ANS has 2 branches or sides that oppose each other, when one becomes active it switches off the other side and vice versa it’s like a seesaw as one side goes up the other side goes down.
 
When we are stressed the sympathetic branch becomes dominant and the parasympathetic is switched off, when we are relaxed the parasympathetic branch becomes dominant and the sympathetic system is switched off.
 
I’m sure you know when we are stressed the response in our body’s physiology is that certain parts of our body become more active like the heart for example but what you might not realise is that when we become relaxed the response in our body is not just to reduce activity in the areas that become active when we are stressed but in a relaxed parasympathetic dominant state certain areas of the body also become more active: for example when we have a stress response the heart works harder and the digestive system becomes quite inactive conversely when we have a relaxation response the heart rate slows down but our intestines become more active and work much harder, they get more blood supply, increase the production of digestive enzymes, they initiate increased muscular contractions including peristalsis and MMC motions.
 
The vagus nerve is the largest nerve in the body and it’s part of the parasympathetic branch of the autonomic nervous system, the vagus nerve conveys relaxation response signals to several major organs in the body, for example activation of the vagus nerve tells the heart to relax and the digestive system to become active; activation of the vagus nerve also tells the body to switch off inflammation. Training the vagus nerve to become more active improves heart health, lowers blood pressure, reduces inflammation including inflammation in the intestines, improves immune health, blood sugar metabolism and improves intestinal motility and digestion.
 
To this day mainstream medical textbooks still say that ANS a self autonomous system that regulates our stress physiology independently of our conscious mind in other words it said you can’t command your body to go into a parasympathetic dominant state. It’s true that we cannot directly command our heart to squeeze and then relax in the same way that we can command our hand to make a fist and an open; but we can train our mind to conjure up a psychological state that induces relaxation response, change our breathing and relax key spots in our body and by doing so we can ‘command’ our ANS to switch from sympathetic dominant to parasympathetic dominant.
 
The proof that this is achievable is that within a few minutes of performing these exercises you can objectively measure a slowing down in your heart rate, an increase in what’s called heart rate variance, a reduction in blood pressure, an increase in the temperature of your hands and feet (blood flow to the periphery increases as the parasympathetic nervous system becomes dominant), you can measure these things with cheap readily available fitness watches, blood pressure meter
 
In clinical practice was more important than measuring these changes is producing therapeutic effects, I 1st used these techniques in myself to finally eradicate the IBS I used to have and then began teaching them to my patients in the early 90s, since then I’ve taught literally hundreds of people how to do these exercises with consistently good results and surprisingly powerful and far-reaching effects.
 
The classic scientific model misrepresents the relationship between our conscious mind, our central nervous system and our autonomic nervous system, it doesn’t convey how in the real world we can train our brain to change the way it handles our stress physiology and obtain real lasting therapeutic and side-effect free benefits so for example could do things like lower high blood pressure by 10 to 15 points, though our blood sugar, lower our cholesterol, lower nighttime cortisol, improve our adrenal function, improve our sleep, improve our immune system, improve and combat digestive and mental health problems.
 

Training your brain to activate the vagus nerve

The brain training exercises to increase activity in the vagus nerve is the same as the brain training exercise to switch the ANS into a parasympathetic dominant condition. The training programme I use has got 2 parts:
  • once a day you lie on your back and perform a 20 minute whole-body very deep relaxation (I have separate written and audio instructions for this available on request),
  • about 5 times a day you perform a 2 minute ‘mini’ relaxation technique which with practice you can do sitting upright with your eyes open while watching the television or sitting at your desk. (I have separate written instructions for this).
 
The relaxation response brain training exercise you can use to change the balance in your ANS will also switch off activity in another stress pathway in the body called the HPA axis. Overactivity in the HPA axis can cause adrenal fatigue, it can further contribute to weakening the intestinal lining causing leaky gut and directly produce inflammation in the brain that can alter the function in key structures of the brain that control mood and memory, so you should also do this exercise for the health of your brain even if you have no obvious digestive health issues. See The BDNF Hypothesis of Depression and Mental Health Problems, the Cytokine Hypothesis
 
From IBS/SIBO through adrenal fatigue, leaky gut, systemic and neuro inflammation to diminished neuroplasticity causing mental health problems or diminished cognitive abilities performing 50 hours of brain training to learn how to semiautomatically switch from a sympathetic dominant to a parasympathetic dominant state can in my opinion make or break the success of your treatment. Learning a new skill and hardwiring it into the brain so that it becomes semiautomatic requires a lot of hours of training, evidence of rewiring in the brain has been observed in brain scans with as little as 30 hours of meditation but my clinical observation is this minimum threshold is not good enough and what I prescribe is 50 hours of training to hardwire the skills into the semiautomatic subconscious parts of your brain; 50 hours requires 20 minutes a day for about 6 months.
 

But can we train our mind to switch on migrating motor complexes?

Although increasing activity in the vagus nerve improves digestion overall it is not clear scientifically if increasing vagal tone/activity will directly increase MMC movements; it may be that improving vagal tone may improve the digestion of breakdown and absorption nutrition from food it may not directly be responsible for the next thing that’s supposed to happen in the small intestines which is that the food residue left behind after we’ve digested it should be swept away down into the large intestines were our intestinal microbiota bacteria goes to work on it.
 
The migrating motor complex movements are directly under the control of a 3rd nervous system in our body called the enteric or gut nervous systems. The enteric nervous system is also said to be outside our conscious control and my personal experience is it may well be harder to use our mind to interact with our enteric nervous system then it is to use a mind to interact with our autonomic nervous system.
 
I’ve been experimenting to see if I can entrain my brain to switch on MMC motions. You can tell when you’re having the final stage of an MMC motion buy the really loud rumbling sounds produced from the intestines, they are easily distinguishable from the peristaltic sounds that you usually need a stethoscope to hear.
 
MMC motions are inhibited by several things, there are inhibited by sleep which is a pity, if the intestines could clean himself while we slept it could eliminate SIBO every night, they are inhibited by some food poisoning infections (e.g. Salmonella) so these have to be eliminated first and MMC motions are inhibited for an hour and a half to 2 hours after we eat.
 

The MMC activation brain training technique

What I’ve been trying is making a point of having nothing but water or tea for 2 ½ hours before going to bed and then lying on my back and deliberately focusing my mind into relaxing and breathing into my diaphragm and abdomen. The reason I wait 2 ½ hours after eating is because although the 1st stage of MMC’s may begin in as little as 90 minutes after eating a full MMC cycle itself lasts about an hour and it’s only in the latter stages where we hear the loud audible tell-tale noises.
 
The Procedure
I begin by performing a quick whole-body relaxation (see above) followed by a 2 or more rounds of performing the mini relaxation where you simply relax 7 specific areas of the body.
I then focus specifically on the sensation of relaxing my diaphragm and lower abdomen.
As I try to relax my diaphragm and abdomen I deliberately increase the depth of my breathing into the abdomen, so as I’m inhaling my belly is rising and then as I excel my belly goes down without engaging my chest or shoulders in the breeding motion.
I’m also performing a technique that increases parasympathetic dominance, the technique is to allow or make the in-breath go at a fairly swift pace and then make the out-breath very long and slow, i.e. spend more time breathing out than you spend breathing in. This is sometimes called parasympathetic breathing, it helps because when we inhale our ANS shifts its balance towards a sympathetic state and when we exhale the ANS shifts its balance towards a relaxing parasympathetic state so when we spend more time exhaling than inhaling we spend more time in a parasympathetic dominant state.
It’s early days but I’m also convinced that specifically focusing on relaxing my throat (which is part of the mini relaxation) contributes to initiating MMC activity; although this may just be a significant component in my individual case and for other people there might be other spots of the body which when deliberately relaxed will have a significant effect for them (please send me any feedback on this if you get).
 
When I 1st tried this procedure it was disheartening, I practised for about 40 minutes a day for 2 weeks without any signs or feelings that I was achieving anything. After 2 weeks however I began to hear loud MMC gurgling noises within about 30 minutes of starting the technique, I also became aware of what felt like knots or balls of tension moving around my abdomen. Actually as I would do the exercise rather than my abdomen feeling like it was relaxing that she just felt like I became more aware of how the tension I was holding their; but nevertheless the sounds were occurring on cue
 
Once I had honed in on what seemed to be the key components of performing parasympathetic breathing (quick inhale longer slow exhale) into my abdomen whilst concentrating on relaxing my throat and diaphragm I began to be able to trigger loud MMC gurgling noises in less time eventually as I write this I can trigger those sounds within 10-11 minutes of commencing the technique.
 
At the time of writing this I’ve only shared the technique with a few people and I’m still working out what are the essential components and how to effectively teach it communicated but early indications are that we can indeed use our conscious mind to switch off stress responses that are inhibiting our enteric nervous system from switching on MMC motions keeping our small intestines free from bacterial overgrowth.
 

Coffee Enemas stimulates the vagus nerve/gut motility

In the beginning it’s perfectly okay to do a coffee enema once or twice a day, coffee enemas stimulates the bowels and do not lead to a weakening of the bowels or dependency; as part of filling my IBS I performed to coffee enemas a day for several months then one coffee enema a day for almost a year and then simply stopped and my bowels return to and maintain normal healthy daily function.
 
Instructions for Coffee Enemas
  • Use organic coffee made from ground beans not instant.
  • Use 3 rounded desert spoons.
 
HOT BREW METHOD
  • You can either put the coffee in a pan with about a litre (2 pints) of bottled or filtered water bring it to the boil and leave it to stand for 8-10 minutes; or put the coffee into a large cafeteria (French press), pouring boiling water and leave it to stand for 8-10 minutes with the filter up to allow the coffee room to move.
  • If you’ve used a pan strain the coffee through a very fine sieve or straining cloth or if you use a cafeteria press the filter down to separate the grouts.
COLD BREW METHOD
I highly recommend getting into cold brew coffee, it tastes better, preserves the medicinal properties and it’s easy to make, you can see how to make a brew coffee online, YouTube etc.
  • If you have ready-made cold-brew coffee use an amount equivalent to about 2 ½ espresso shots for the enema.
  • Now adjust the volume of the liquid to equal about 1 L or 2 pints and bring the temperature to 38-40°C (100-104°F)
TO TAKE:
  • I suggest you make your first enema 1/2 size to get the hang of it.
  • Make sure the liquid is at body temperature 38-40°C (100-104°F) DO NOT SCALD YOUR COLON.
  • Add coffee to the enema kit with the tap close then let all the air out of the tube, you don’t want daring that you going into your colon, it’s not harmful it just makes it impossible to hold; to remove the air simply open the tap and run the coffee through.
  • Hang the bucket NO MORE THAN ABOUT 1 metre (3½ feet) ABOVE YOUR BODY.  You can hang the bag/bucket on a hook or use string to tie it to a door handle, window, shower tap etc.
  • Lie initially on your left side with your knees bent up towards your chest.
  • Lubricate the nozzle (with KY jelly or moisturiser, insert into the rectum and open the tap to let the coffee drain into the body. If the liquid does not begin to flow when you open the tap try changing the position/angle of the nozzle, you may need to move it slightly out or hold it centred.  Once all the liquid has drained close the tap, remove the nozzle and wrap in a tissue.
  • Rollover onto your right side and retain the coffee for 15 minutes while relaxing before release it into the toilet.
  • If you feel a strong urge to expel the enema, it will usually only last for a minute or so.  You can control this by breathing very quickly in and out of the abdomen, the breath should be done by pumping the abdominal muscles.  Another helpful technique that you can do at the same time is to rotate your feet in circles at the ankles.  Do these until the urgency to expel the liquid passes.
  • If the urge to release the enema is too strong then simply go to the toilet and start again.  If you are constipated backed up and think it is likely you could not hold the full enema could have a quick warm coffee or plain water enema first to clear the way.
  • If the liquid hits a block of impacted faeces you may feel some discomfort, simply stop the flow of coffee and massage the area.
  • Coffee is a diuretic and you may find that about an hour after the enema you have an urgent need to urinate, so it is a good idea to have access to a toilet and not have an enema before going out.
  • Never have a coffee enema when you are dehydrated, your body will try to hydrate itself by using the water in the enema and you may find it difficult to expel the enema; if you are dehydrated spend several hours hydrating before the enema.
  • You may lose some potassium salts from your body when you do an enema so you should only be doing coffee enemas if you’re consuming very large amounts of vegetables including vegetable smoothies and some bananas.
NOTE:
Good hygiene is obviously important!  The oil in the coffee tends to build up on the inside of the tube, can be removed by running hot soapy water through the tube whilst squeezing and rolling each part of the tube between fingers and thumb (if you have a plastic bag coffee enema and you use very hot water you will quickly break down the glue holding the bag together.  The beginning of the tube and the inside of the tap can be cleaned with a plastic wire tie.
 

Tongue massage/gag-reflex stimulates the vagus nerve

Okay this one sounds strange but it’s actually quite powerful. You could use the handle of a spoon or just your own clean fingers (but not if you have long fingernails), but the handle of spoon or your finger onto the back of your tongue and press down in a way that initiates your gag reflex, you should feel the gag reflex in your throat and the muscles in your stomach or abdomen should contract. Provoke 5-10 gag reflexes 2 or 3 times a day.
 
Gargling stimulates the vagus nerve
The vagus nerve runs through the neck/throat and we can stimulate it with regular gargling. It will take several weeks of gargling 2 or ideally 3 times a day before gargling will produce any significant effects on the vagus nerve.
 
Actually humming that vibrates the throat also stimulates the vagus nerve and you can combine this with gargling, when you gargle do it in a way that produces a humming/vibration in your throat, gargle for a full minute to produce a therapeutic effect.
 

Abdominal Self Massage

Lying on your back with your feet flat on the ground and your knees bent massage your abdomen in a clockwise direction and also using your thumbs massage in small sweeping motions from your navel outwards to the sides of your abdomen in all directions rather like tracing the spokes on a wheel from the centre to the rim. You can massage deeply and firmly however you should be guided by your own pain, the gentle on painful areas just persist gradually massaging until the pain subsides.
 
You can perform abdominal self massage using oil on the abdomen such as olive or castor oil or do it lying in the bath 2-3 times a week.
 
The cholinergic anti-inflammatory pathway depicted.
Scheme of the vagus nerve interacting with immune activation at multiple levels following ingestion, infection, and trauma. (1) During digestion, the commensal flora and dietary components activate the sensory afferent vagus nerve, which will transmit the information to the brain. In return, the brain may activate the efferent vagus nerve to modulate gastrointestinal macrophages. (2) The efferent vagus nerve also modulates systemic inflammatory responses through a mechanism involving an intact spleen. Upon infection or trauma, bacterial components or intracellular mediators (HMGB1, heat shock proteins, etc.) activate macrophages to produce proinflammatory cytokines. (3) This will trigger afferent vagus nerve signaling. (4) Central activation of vagal efferent pathways which lead to release of acetylcholine (ACh) and relay on peripheral ganglia to stimulate adrenergic transmitter release (in the spleen) to act on aplenic antigen presenting cells and macrophages. Recent data indicate the generation of ChAT-positive ACh producing immune cells (see text). Interrogation marks indicate that, although macrophages are found in the proximity of cholinergic fibers in the spleen and the intestine, there is currently no evidence demonstrating that parasympathetic neurons, indeed, innervate immune cells in the gut wall. HMGB1: high-mobility group box 1.
 

Healing Leaky Gut

Zinc Carnosine
1 capsule twice a day with meals.
Zinc-carnitine is a specialist form of zinc that protects the lining of the intestines and stimulates regeneration.
https://www.iherb.com/pr/Doctor-s-Best-Zinc-Carnosine-Complex-with-PepZin-Gl-120-Veggie-Caps/2467?gclid=EAIaIQobChMIysi5kOrs1gIVk5EbCh01TADjEAQYASABEgI6RfD_BwE
 
Chicken stock
3 to 5 litres per week, see Health Benefits of Chicken Stock
 
Slippery elm
2 heaped desert spoons of slippery elm powder 2 to 3 times per day on an empty stomach mixed in with fluids, kefir or yoghurt.
 
Marigold flower
Fushi magnolia flower tincture 1-2 pipettes full 3 times a day even
 
REFERENCES
[i] Forsch Komplementarmed Klass Naturheilkd. 2002 Dec;9 Suppl 1:1-20.
[Iberogast: a modern phytotherapeutic combined herbal drug for the treatment of functional disorders of the gastrointestinal tract (dyspepsia, irritable bowel syndrome)--from phytomedicine to "
evidence based phytotherapy." A systematic review].
[Article in German] Saller R1, Pfister-Hotz G, Iten F, Melzer J, Reichling J. PMID: 12618546 DOI: 10.1159/000068645
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Hi my name is Peter Smith I specialise in treating and coaching people how to live well with mental health problems, digestive health problems/IBS, sleep problems and type II diabetes using natural therapies.
I used these techniques to overcome and live well with my own bipolar disorder and IBS. I've been in practice as a natural medicine practitioner since 1988.
 

What I Treat

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